Advertisement By: Christopher Lampton ATMs are fast and convenient, but they can also cost you money. Let's consider some alternatives to hitting the local ATM every other day. For one, you could keep a healthy amount of cash on hand. OK, t

13 Feb 2019 Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Toxoplasma gondii Agent. Frontiers in cellular and infection microbiology, 9, 26.

As an ATM inhibitor, KU-55933 significantly inhibited the increase of phospho-Akt at Ser473 in MDA-MB-453 and PC-3 cells treated with insulin and IGF-I following serum starvation. In the MTT assay, KU-55933 treatment suppressed cell proliferation by about 50% at concentration of 10 μM in MDA-MB-453 and PC-3 cells. Functional Studies - KU-55933, competitive ATM kinase inhibitor (ab120637) HepG2 cells were incubated at 37°C for 60 minutes with vehicle control (0 µM) and different concentrations of KU-55933 (ab120637). As an ATM inhibitor, KU-55933 significantly inhibited the increase of phospho-Akt at Ser473 in MDA-MB-453 and PC-3 cells treated with insulin and IGF-I following serum starvation. In the MTT assay, KU-55933 treatment suppressed cell proliferation by about 50% at concentration of 10 μM in MDA-MB-453 and PC-3 cells.

Ku55933 atm inhibitor

trusted source for researchers and distributors. The inhibition of kinase ATR with its specific inhibitor VE-821 resulted in a more pronounced radiosensitizing effect in HL-60 cells as compared to the inhibition of kinase ATM with the inhibitor KU55933. In contrast to KU55933, the VE-821 treatment prevented HL-60 cells from undergoing G2 cell cycle arrest. Notably, the ATM knockdown cells proliferated at a similar rate to control cells, suggesting that ATM does not influence cell viability in the absence of FLT3 inhibition. To determine if pharmacological inactivation of ATM has similar effects as genetic inactivation, we used the ATM kinase inhibitor KU55933.

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Pharmacological ATM inhibition by KU55933 in cisplatin-treated mice did not ameliorate, but instead exacerbated cisplatin-induced DnA damage and tubular

Let's consider some alternatives to hitting the local ATM every other day. For one, you could keep a healthy amount of cash on hand. OK, t Over the past couple years, the innovations coming out of the ATM industry have escalated. ATM manufacturers are developing numerous ways to add to the so-called convenience society that ATMs helped initiate.

Here we demonstrate that the treatment of intracellular tachyzoites with the PI3K inhibitor caffeine or ATM kinase-inhibitor KU-55933 affects parasite replication rate in a dose-dependent manner. KU-55933 affects intracellular tachyzoite growth and induces G1-phase arrest.

OK, t Over the past couple years, the innovations coming out of the ATM industry have escalated. ATM manufacturers are developing numerous ways to add to the so-called convenience society that ATMs helped initiate. How much do you know about what A checking account gives you a place to store cash that you can access easily by writing checks or paying with a debit card. Some businesses, however, don't accept checks or debit card payments, so you may have to withdraw cash from your ch ''You can stop at an ATM, enter a PIN and leave with cash. Learn about the machines that give you money and the network that approves the transactions!'' Advertisement By: Jim Bowen You're short on cash, so you walk over to the autom Sometimes called antiangiogenic therapy, this treatment may prevent the growth of cancer by blocking the formation of new blood vessels.

For one, you could keep a healthy amount of cash on hand. OK, t Over the past couple years, the innovations coming out of the ATM industry have escalated. ATM manufacturers are developing numerous ways to add to the so-called convenience society that ATMs helped initiate. How much do you know about what A checking account gives you a place to store cash that you can access easily by writing checks or paying with a debit card. Some businesses, however, don't accept checks or debit card payments, so you may have to withdraw cash from your ch ''You can stop at an ATM, enter a PIN and leave with cash. Learn about the machines that give you money and the network that approves the transactions!'' Advertisement By: Jim Bowen You're short on cash, so you walk over to the autom Sometimes called antiangiogenic therapy, this treatment may prevent the growth of cancer by blocking the formation of new blood vessels.
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KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。. KU-55933 is a specific ATM inhibitor with IC50 value of 13nM and Ki value of 2.2nM View and buy high purity KU 55933 from Tocris Bioscience. Potent and selective ATM kinase inhibitor. Cited in 77 publications. KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

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Here we demonstrate that the treatment of intracellular tachyzoites with the PI3K inhibitor caffeine or ATM kinase-inhibitor KU-55933 affects parasite replication rate in a dose-dependent manner. KU-55933 affects intracellular tachyzoite growth and induces G1-phase arrest.

KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/K i of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription. Experimental Biology and Medicine, 2012.

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2012-11-21 · KU-55933 is a specific inhibitor of the kinase activity of the protein encoded by Ataxia telangiectasia mutated (ATM), an important tumor suppressor gene with key roles in DNA repair. Unexpectedly for an inhibitor of a tumor suppressor gene, KU-55933 reduces proliferation. In view of prior preliminary evidence suggesting defective mitochondrial function in cells of patients with Ataxia

Moreover, KU-55933 inhibits cancer cell proliferation by inducing G (1) cell cycle arrest. KU55933 inhibits insulin- and IGF1-stimulated Akt phosphorylation at both Ser473 and Thr308. A ATM cellular inhibition by KU55933 was demonstrated in additional phosphorylation targets, including p53 Ser15, H2AX Ser139, NBS1 Ser343, Chk1 Ser345, and SMC1 Ser966. KU-55933 is a potent ATM inhibitor with an IC50 and K of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. For research use only. We do not sell to patients.